USP General Chapter 71: difference between revisions
Diff·revision 11 → 12·23:00, 29 Mar 2025
Difference between revision 11 and revision 12 of USP General Chapter 71. 2 lines changed; the page grew by 271 bytes.
| Revision 11 — 14:58, 11 Mar 2025 AnalyticalAnnie (talk) fix the anchor on an internal link 3,092 bytes +122 | Revision 12 — 23:00, 29 Mar 2025 CategoryBot (talk) bot: flag bare reference 3,363 bytes +271 | ||
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| 26 | The pore size is a compendial convention rather than an absolute cut-off. Organisms smaller than the nominal rating exist, and filtration is a retention process rather than a sieve, so retention is probabilistic. This is one of several reasons the chapter is framed as a test rather than as proof. | 26 | The pore size is a compendial convention rather than an absolute cut-off. Organisms smaller than the nominal rating exist, and filtration is a retention process rather than a sieve, so retention is probabilistic. This is one of several reasons the chapter is framed as a test rather than as proof. |
| 27 | 27 | ||
| + | 28 | For a lyophilised powder, filtration requires dissolution in a suitable diluent, which introduces a step at which contamination can be added or an inhibitory solvent can interfere. The suitability demonstration covers this, which is why it is not optional.{{r|usp1211}} | |
| + | 29 | ||
| 28 | == References == | 30 | == References == |
| 29 | {{reflist}} | 31 | {{reflist}} |