Peptide stability table: difference between revisions
Diff·revision 31 → 32·14:19, 23 May 2025
Difference between revision 31 and revision 32 of Peptide stability table. 7 lines changed; the page grew by 756 bytes.
| Revision 31 — 21:30, 13 May 2025 IncretinIvo (talk) merge two short sections 4,135 bytes ±0 | Revision 32 — 14:19, 23 May 2025 MoveRequestMio (talk) state the assay for the reference interval 4,891 bytes +756 | ||
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| 31 | {{note|An interval is not a cliff. A 28-day figure means the formulation was shown to remain within specification for 28 days under the stated conditions; it does not mean the material is inert on day 27 and unusable on day 29, nor that it was ever tested on day 40.}} | 31 | {{note|An interval is not a cliff. A 28-day figure means the formulation was shown to remain within specification for 28 days under the stated conditions; it does not mean the material is inert on day 27 and unusable on day 29, nor that it was ever tested on day 40.}} |
| 32 | 32 | ||
| + | 33 | == Why cross-source comparison is unsafe == | |
| + | 34 | Four differences between sources make two stability figures incomparable even when both are honestly reported. | |
| + | 35 | ||
| + | 36 | '''The specification differs.''' "Stable for 28 days" means "remained within the specification" and specifications differ. A limit of 95% of label potency and a limit of 90% produce different intervals from identical data. | |
| + | 37 | ||
| + | 38 | '''The assay differs.''' A stability-indicating [[High-performance liquid chromatography|HPLC]] method that resolves the principal degradant reports loss that a method which co-elutes it does not. [[Analytical method validation|Method validation]] is what establishes that a method is stability-indicating, and research-compound figures rarely state whether it was.{{r|ich}} | |
| + | 39 | ||
| 33 | == References == | 40 | == References == |
| 34 | {{reflist}} | 41 | {{reflist}} |