PeptidePedia The community reference

Peptide stability table (revision 31)

Old revision·21:30, 13 May 2025·IncretinIvo

This is an old revision of this page, as it stood at 21:30, 13 May 2025, saved by IncretinIvo with the summary merge two short sections. It may differ substantially from the current revision, and any error it contains may since have been corrected.
This article relies excessively on primary sources. (September 2025) Discussion: Sourcing of the reconstituted-stability column.
Peptide stability tableInteractive reference tool
Synthesis25°−2025°Air15°Customs12°2–88°End8°temperature exposure along the chaina single excursion above 25 °C is enough to force re-testing
Temperature exposure accumulates along the chain; a stability figure describes one segment of it.
Rows28 compounds
ColumnsLyophilised and reconstituted storage, diluent, notes
Caveats
ComparabilityLow — conditions and assays differ by source
BasisManufacturer labelling where available, otherwise published stability studies
Not coveredSterility, endotoxin, container-closure integrity
Reference tool infobox · conventions

The peptide stability table collects reported storage conditions and stability intervals for compounds covered on this wiki. It is a navigational and comparative aid rather than a source in its own right: every figure in it is attributable to labelling or to a published study, and the two are not equivalent evidence.

Stability is a property of a formulation in a container under conditions, not of a molecule. The same peptide may carry a 36-month shelf life as a manufactured product and no meaningful stability claim at all as a lyophilised research powder in an unspecified vial, because nobody has run the study.[1] Where the table records a figure for a research compound, that figure is almost always extrapolated from a related product or from a small published study, and the notes column says so.

Compounds distributed for research are not approved for human use, and no stability figure in this table implies that any material is fit for any purpose. Sterility and endotoxin content are not stability properties and are not covered here.

The table

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Filter by compound name, or by storage class. Sorting is available on every column.

How to read the columns

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Lyophilised
Conditions and interval reported for the dry solid in its sealed container. A lyophilised peptide is far more stable than the same peptide in solution, because the degradation pathways that matter — deamidation, oxidation and aggregation — all require water or mobility.[2]
Reconstituted
Conditions and interval after dissolution. This is the column with the weakest sourcing across the table, and the one carrying the maintenance banner: for approved products it comes from labelling, and for research compounds it is usually an extrapolation.
Diluent
What the figure applies to. Bacteriostatic water and unpreserved water are not interchangeable for the purpose of a storage interval, because the interval for a multi-puncture container depends on the preservative.
Light
Whether photodegradation is reported as significant. Tryptophan- and tyrosine-containing sequences are the usual concern.
Basis
Whether the row rests on manufacturer labelling, a published stability study, or an extrapolation. Rows marked extrapolated should not be cited as evidence about the compound named.
An interval is not a cliff. A 28-day figure means the formulation was shown to remain within specification for 28 days under the stated conditions; it does not mean the material is inert on day 27 and unusable on day 29, nor that it was ever tested on day 40.

See also

References

  1. ^ International Council for Harmonisation, Q1A(R2): Stability Testing of New Drug Substances and Products (2003).
  2. ^ Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. "Stability of protein pharmaceuticals: an update." Pharmaceutical Research 27(4):544–575 (2010). DOI:10.1007/s11095-009-0045-6. PMID 20143256.
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