Gastric emptying: difference between revisions
Diff·revision 2 → 3·00:01, 13 Aug 2024
Difference between revision 2 and revision 3 of Gastric emptying. 6 lines changed; the page grew by 884 bytes.
| Revision 2 — 13:25, 8 Aug 2024 AnalyticalAnnie (talk) add see also to the sister hormone 1,386 bytes ±0 | Revision 3 — 00:01, 13 Aug 2024 Peptide_Pete (talk) add the counter-regulatory glucagon point, sourced 2,270 bytes +884 | ||
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| 10 | Delayed emptying is one of the principal actions of [[GLP-1 receptor agonist|GLP-1 receptor agonists]]. It blunts the postprandial glucose excursion by delivering carbohydrate to the absorptive surface more slowly, and it contributes to early satiety through gastric distension. In short-acting agonists it accounts for a substantial part of the postprandial glycaemic effect.{{r|marathe2013}} | 10 | Delayed emptying is one of the principal actions of [[GLP-1 receptor agonist|GLP-1 receptor agonists]]. It blunts the postprandial glucose excursion by delivering carbohydrate to the absorptive surface more slowly, and it contributes to early satiety through gastric distension. In short-acting agonists it accounts for a substantial part of the postprandial glycaemic effect.{{r|marathe2013}} |
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| + | 12 | == Normal physiology == | |
| + | 13 | Liquids empty approximately exponentially and rapidly; solids empty after a lag phase during which food is triturated to particles small enough to pass the pylorus, then at an approximately linear rate. A half-emptying time of about 45–90 minutes is usual for a standard solid meal, with wide interindividual variation.{{r|marathe2013}} | |
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| + | 15 | Rate is regulated to deliver nutrient to the small intestine at a roughly constant caloric rate, near 2 kcal per minute, regardless of meal composition. The regulator is feedback from nutrient sensing in the duodenum and ileum, mediated by cholecystokinin, [[Glucagon-like peptide-1|GLP-1]], peptide YY and neural reflexes — the so-called ileal brake.{{r|holst2007}} | |
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| 12 | == References == | 17 | == References == |
| 13 | {{reflist}} | 18 | {{reflist}} |
| 14 | <ref name="marathe2013">Marathe CS, Rayner CK, Jones KL, Horowitz M. "Relationships between gastric emptying, postprandial glycemia, and incretin hormones." ''Diabetes Care'' 36(5):1396–1405 (2013). DOI:10.2337/dc12-1609. PMID 23613599.</ref> | 19 | <ref name="marathe2013">Marathe CS, Rayner CK, Jones KL, Horowitz M. "Relationships between gastric emptying, postprandial glycemia, and incretin hormones." ''Diabetes Care'' 36(5):1396–1405 (2013). DOI:10.2337/dc12-1609. PMID 23613599.</ref> |
| + | 20 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). PMID 17928588.</ref> | |
| 15 | 21 | ||
| 16 | {{DEFAULTSORT:Gastric emptying}} | 22 | {{DEFAULTSORT:Gastric emptying}} |