Enteroendocrine L cell: difference between revisions

Diff·revision 9 → 10·16:27, 16 Aug 2024

Difference between revision 9 and revision 10 of Enteroendocrine L cell. 2 lines changed; the page grew by 362 bytes.

Revision 9 — 00:16, 10 Aug 2024 GsCouplingGil (talk) move table to the section it supports 2,224 bytes ±0	Revision 10 — 16:27, 16 Aug 2024 SPPS_Sorrel (talk) add hatnote 2,586 bytes +362
3	L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r\|furness2013}}	3	L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r\|furness2013}}
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+		5	L cells are sparse in the duodenum and jejunum but become progressively more frequent in the ileum, where they account for approximately 1% of epithelial cells. They are most abundant in the distal ileum and right colon, positions that allow them to sense the end products of colonic bacterial fermentation, particularly short-chain fatty acids.{{r\|holst2007}}
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5	== Morphology and distribution ==	7	== Morphology and distribution ==
6	L cells are polarised epithelial cells with microvilli on the apical surface and secretory granules in the basolateral cytoplasm. The apical surface, open to the lumen, serves as the nutrient-sensing compartment; the basolateral surface contains receptors and ion channels that relay signals to the secretory machinery. L cells represent approximately 0.5–1% of all intestinal epithelial cells overall but are far more frequent in the ileum and colon than the duodenum.{{r\|furness2013}}	8	L cells are polarised epithelial cells with microvilli on the apical surface and secretory granules in the basolateral cytoplasm. The apical surface, open to the lumen, serves as the nutrient-sensing compartment; the basolateral surface contains receptors and ion channels that relay signals to the secretory machinery. L cells represent approximately 0.5–1% of all intestinal epithelial cells overall but are far more frequent in the ileum and colon than the duodenum.{{r\|furness2013}}

Revision 9 — 00:16, 10 Aug 2024 GsCouplingGil (talk) move table to the section it supports 2,224 bytes ±0	Revision 10 — 16:27, 16 Aug 2024 SPPS_Sorrel (talk) add hatnote 2,586 bytes +362
3	L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r\|furness2013}}	3	L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r\|furness2013}}
4		4
+		5	L cells are sparse in the duodenum and jejunum but become progressively more frequent in the ileum, where they account for approximately 1% of epithelial cells. They are most abundant in the distal ileum and right colon, positions that allow them to sense the end products of colonic bacterial fermentation, particularly short-chain fatty acids.{{r\|holst2007}}
+		6
5	== Morphology and distribution ==	7	== Morphology and distribution ==
6	L cells are polarised epithelial cells with microvilli on the apical surface and secretory granules in the basolateral cytoplasm. The apical surface, open to the lumen, serves as the nutrient-sensing compartment; the basolateral surface contains receptors and ion channels that relay signals to the secretory machinery. L cells represent approximately 0.5–1% of all intestinal epithelial cells overall but are far more frequent in the ileum and colon than the duodenum.{{r\|furness2013}}	8	L cells are polarised epithelial cells with microvilli on the apical surface and secretory granules in the basolateral cytoplasm. The apical surface, open to the lumen, serves as the nutrient-sensing compartment; the basolateral surface contains receptors and ion channels that relay signals to the secretory machinery. L cells represent approximately 0.5–1% of all intestinal epithelial cells overall but are far more frequent in the ileum and colon than the duodenum.{{r\|furness2013}}