Bacterial endotoxin test: difference between revisions
Diff·revision 4 → 5·16:18, 27 Sep 2024
Difference between revision 4 and revision 5 of Bacterial endotoxin test. 2 lines changed; the page grew by 297 bytes.
| Revision 4 — 14:14, 17 Sep 2024 AnalyticalAnnie (talk) split overlong sentence 2,127 bytes ±0 | Revision 5 — 16:18, 27 Sep 2024 KarlFischerKit (talk) add the counterion determination method by name 2,424 bytes +297 | ||
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| 16 | Recombinant factor C assays, which use a recombinant version of the initiating enzyme rather than crab-derived lysate, have been introduced and are increasingly accepted. They avoid the animal-derived reagent and are more specific, since they respond only to endotoxin and not to β-glucans. | 16 | Recombinant factor C assays, which use a recombinant version of the initiating enzyme rather than crab-derived lysate, have been introduced and are increasingly accepted. They avoid the animal-derived reagent and are more specific, since they respond only to endotoxin and not to β-glucans. |
| 17 | 17 | ||
| + | 18 | Interference is the routine difficulty. Sample matrices can enhance or inhibit the cascade, so a validated method includes a positive product control demonstrating recovery of a known spike. A result reported without evidence that interference was assessed is not fully interpretable.{{r|usp85}} | |
| + | 19 | ||
| 18 | == References == | 20 | == References == |
| 19 | {{reflist}} | 21 | {{reflist}} |