Amylin: difference between revisions
Diff·revision 21 → 22·12:19, 17 Jul 2025
Difference between revision 21 and revision 22 of Amylin. 5 lines changed; the page grew by 650 bytes.
| Revision 21 — 10:11, 22 Jun 2025 TirzTaxonomist (talk) add the peptide length to the infobox 4,449 bytes +172 | Revision 22 — 12:19, 17 Jul 2025 AnalyticalAnnie (talk) state which salt form the mass in the infobox refers to 5,099 bytes +650 | ||
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| 39 | Because the receptor family overlaps with that for calcitonin and calcitonin gene-related peptide, selectivity is a real design constraint for analogues, and cross-activity at the calcitonin receptor is one route by which a long-acting analogue can produce effects beyond appetite.{{r|hay2015}} | 39 | Because the receptor family overlaps with that for calcitonin and calcitonin gene-related peptide, selectivity is a real design constraint for analogues, and cross-activity at the calcitonin receptor is one route by which a long-acting analogue can produce effects beyond appetite.{{r|hay2015}} |
| 40 | 40 | ||
| + | 41 | == Amyloid formation == | |
| + | 42 | Human amylin aggregates readily into cross-β fibrils; rodent amylin, which differs at several proline-containing positions, does not. This species difference is why rodent models do not spontaneously develop islet amyloid and why transgenic models were needed to study it.{{r|westermark2011}} | |
| + | 43 | ||
| + | 44 | Islet amyloid is present in the majority of pancreases examined post mortem from people with long-standing type 2 diabetes. Whether it is a cause of beta-cell loss or a consequence of prolonged secretory stress remains debated; oligomeric intermediates rather than mature fibrils are the species most often proposed as cytotoxic. | |
| + | 45 | ||
| 41 | == References == | 46 | == References == |
| 42 | {{reflist}} | 47 | {{reflist}} |