Vial filling and stoppering: difference between revisions
Diff·revision 9 → 10·21:27, 20 Feb 2025
Difference between revision 9 and revision 10 of Vial filling and stoppering. 8 lines changed; the page grew by 312 bytes.
| Revision 9 — 05:28, 9 Feb 2025 DiluentDiya (talk) add the crimp-seal step to the fill-and-finish description 3,355 bytes ±0 | Revision 10 — 21:27, 20 Feb 2025 ForestPlotFinn (talk) close an unbalanced quotation mark 3,667 bytes +312 | ||
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| 1 | {{Infobox method | 1 | {{Infobox method |
| 2 | | name = Vial filling and stoppering | 2 | | name = Vial filling and stoppering |
| + | 3 | | subtitle = Fill and finish | |
| 3 | | image = vial.svg | 4 | | image = vial.svg |
| 4 | | Determines = Fill mass, headspace, container integrity | 5 | | Determines = Fill mass, headspace, container integrity |
| ⋮ | ⋮ | ||
| 24 | 25 | ||
| 25 | An aluminium seal is crimped over the stopper to hold it in place. A loose crimp, a stopper that has lifted, or a cracked flange are the visible defects; container closure integrity is formally established by test rather than by inspection.{{r|usp1207}} | 26 | An aluminium seal is crimped over the stopper to hold it in place. A loose crimp, a stopper that has lifted, or a cracked flange are the visible defects; container closure integrity is formally established by test rather than by inspection.{{r|usp1207}} |
| + | 27 | ||
| + | 28 | | Observable | What it may indicate | | |
| + | 29 | |---|---| | |
| + | 30 | | Loose or spinning crimp | Incomplete seating | | |
| + | 31 | | Lifted stopper | Vacuum lost, or drying incomplete | | |
| + | 32 | | Cracked flange | Handling or transport damage | | |
| + | 33 | | Cake collapse or discolouration | Drying or storage problem, not sealing | | |
| 26 | 34 | ||
| 27 | == References == | 35 | == References == |