Third-party testing: difference between revisions
Diff·revision 21 → 22·03:47, 15 May 2025
Difference between revision 21 and revision 22 of Third-party testing. 8 lines changed; the page grew by 1,136 bytes.
| Revision 21 — 01:12, 26 Apr 2025 Chromatokid (talk) fix a broken wikilink 5,770 bytes ±0 | Revision 22 — 03:47, 15 May 2025 OrforglipronOona (talk) clarify that agreement between certificate and report is a weak finding 6,906 bytes +1,136 | ||
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| 51 | | [[VendorInvestigate]] | Documentary and supply-chain review | | 51 | | [[VendorInvestigate]] | Documentary and supply-chain review | |
| 52 | 52 | ||
| + | 53 | A "PeptideMeter figure" and a "Janoshik result" are therefore not the same kind of object: one is an aggregate over submissions, the other a determination on a sample. Citing them as though they were commensurable is a category error that appears frequently in secondary discussion.{{r|reports}} | |
| + | 54 | ||
| + | 55 | == Reading a report against a certificate == | |
| + | 56 | Where an independent report and a supplier certificate cover the same lot, agreement between them is often presented as validation. It is weaker than that: it establishes that two measurements of the same material agreed, which is expected if both laboratories are competent, and says nothing about whether the material is representative.{{r|usp1503}} | |
| + | 57 | ||
| + | 58 | Disagreement is more informative than agreement, but only if the two determinations are comparable. Two [[Area percent purity|area percent]] figures obtained on different gradients, different columns and different detection wavelengths are not directly comparable, and a difference of a few tenths of a percentage point is within the repeatability of most peptide purity methods. See [[Analytical method validation]]. | |
| + | 59 | ||
| 53 | == References == | 60 | == References == |
| 54 | {{reflist}} | 61 | {{reflist}} |
| ⋮ | ⋮ | ||
| 64 | * [[PeptideMeter]] | 71 | * [[PeptideMeter]] |
| 65 | * [[Area percent purity]] | 72 | * [[Area percent purity]] |
| + | 73 | * [[Peptide content]] | |
| 66 | 74 | ||
| 67 | {{DEFAULTSORT:Third-party testing}} | 75 | {{DEFAULTSORT:Third-party testing}} |