Retention time: difference between revisions
Diff·revision 5 → 6·12:26, 14 Oct 2024
Difference between revision 5 and revision 6 of Retention time. 2 lines changed; the page grew by 256 bytes.
| Revision 5 — 05:57, 27 Sep 2024 SemaxSevi (talk) add the system-suitability criteria the method actually specifies 2,027 bytes +407 | Revision 6 — 12:26, 14 Oct 2024 HypoHildur (talk) add category for method validation 2,283 bytes +256 | ||
|---|---|---|---|
| 17 | Co-injection strengthens it substantially. Spiking the sample with the standard should enlarge the existing peak without producing a shoulder; a shoulder indicates two species. | 17 | Co-injection strengthens it substantially. Spiking the sample with the standard should enlarge the existing peak without producing a shoulder; a shoulder indicates two species. |
| 18 | 18 | ||
| + | 19 | The strongest form combines retention matching with an orthogonal determination — [[Mass spectrometry|mass confirmation]] or a second chromatographic mode with different selectivity. This is what pharmacopoeial identification tests specify.{{r|usp621}} | |
| + | 20 | ||
| 19 | == References == | 21 | == References == |
| 20 | {{reflist}} | 22 | {{reflist}} |