Resin cleavage: difference between revisions
Diff·revision 18 → 19·06:38, 13 Sep 2025
Difference between revision 18 and revision 19 of Resin cleavage. 3 lines changed; the page grew by 281 bytes.
| Revision 18 — 21:12, 9 Aug 2025 StopperingSteff (talk) clarify that the cake appearance is an indicator, not a specification 4,029 bytes ±0 | Revision 19 — 06:38, 13 Sep 2025 ColdChainCleo (talk) expand §Cocktails and scavengers 4,310 bytes +281 | ||
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| 32 | Because these masses are large and distinctive, cleavage-derived impurities are among the easier ones to identify when a full mass spectrum is available — in contrast to deletion sequences and isomers, which need chromatographic resolution.{{r|usp1503}} | 32 | Because these masses are large and distinctive, cleavage-derived impurities are among the easier ones to identify when a full mass spectrum is available — in contrast to deletion sequences and isomers, which need chromatographic resolution.{{r|usp1503}} |
| 33 | 33 | ||
| + | 34 | An itemised related-substances table on a certificate that names such species is showing that the analysis looked for them. One reporting a single aggregate figure is not.{{r|usp621}} | |
| + | 35 | ||
| 34 | == References == | 36 | == References == |
| 35 | {{reflist}} | 37 | {{reflist}} |
| ⋮ | ⋮ | ||
| 37 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | 39 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> |
| 38 | <ref name="aebersold2003">Aebersold R, Mann M. "Mass spectrometry-based proteomics." ''Nature'' 422(6928):198–207 (2003). PMID 12634793.</ref> | 40 | <ref name="aebersold2003">Aebersold R, Mann M. "Mass spectrometry-based proteomics." ''Nature'' 422(6928):198–207 (2003). PMID 12634793.</ref> |
| + | 41 | <ref name="usp621">United States Pharmacopeia, General Chapter <621>, ''Chromatography''.</ref> | |
| 39 | 42 | ||
| 40 | == See also == | 43 | == See also == |