Reconstitution calculator: difference between revisions
Diff·revision 34 → 35·13:06, 11 May 2025
Difference between revision 34 and revision 35 of Reconstitution calculator. 3 lines changed; the page grew by 751 bytes.
| Revision 34 — 09:59, 29 Apr 2025 AnaesthesiaAoife (talk) state the assay for the reference interval 6,229 bytes +222 | Revision 35 — 13:06, 11 May 2025 StubSorterBot (talk) bot: update parent category chain 6,980 bytes +751 | ||
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| 61 | '''Displacement.''' Adding 2 mL of diluent to a vial containing 5 mg of solid produces slightly more than 2 mL of solution, because the dissolved solid occupies volume. For peptide masses of a few milligrams in a millilitre or more of diluent the effect is on the order of a few thousandths of a millilitre and is negligible against the graduation interval of the syringe. It ceases to be negligible when the solid mass approaches the diluent volume, which does not arise in the cases this tool is used for. | 61 | '''Displacement.''' Adding 2 mL of diluent to a vial containing 5 mg of solid produces slightly more than 2 mL of solution, because the dissolved solid occupies volume. For peptide masses of a few milligrams in a millilitre or more of diluent the effect is on the order of a few thousandths of a millilitre and is negligible against the graduation interval of the syringe. It ceases to be negligible when the solid mass approaches the diluent volume, which does not arise in the cases this tool is used for. |
| 62 | 62 | ||
| + | 63 | '''Dead space.''' Volume retained in the syringe hub and needle after the plunger is fully depressed is not delivered. Reported figures range from roughly 0.02 mL for a low-dead-space insulin syringe with a fixed needle to 0.07 mL or more for a detachable-needle arrangement.{{r|whodeadspace}} Against a 0.10 mL dose that is a 20–70% loss if the syringe is not primed, which is why the dead-space field exists: entering a figure shows its effect on the number of doses the vial yields, not on the delivered dose, since a primed syringe delivers its nominal volume. | |
| + | 64 | ||
| 63 | == References == | 65 | == References == |
| 64 | {{reflist}} | 66 | {{reflist}} |
| ⋮ | ⋮ | ||
| 66 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, "Quality Attributes of Synthetic Peptide Drug Substances" (informational). USP–NF, current revision.</ref> | 68 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, "Quality Attributes of Synthetic Peptide Drug Substances" (informational). USP–NF, current revision.</ref> |
| 67 | <ref name="iso7886">ISO 7886-1, ''Sterile hypodermic syringes for single use — Part 1: Syringes for manual use''. International Organization for Standardization.</ref> | 69 | <ref name="iso7886">ISO 7886-1, ''Sterile hypodermic syringes for single use — Part 1: Syringes for manual use''. International Organization for Standardization.</ref> |
| + | 70 | <ref name="whodeadspace">World Health Organization, ''WHO Guideline on the Use of Safety-Engineered Syringes'' (2015) — includes dead-space characterisation of syringe types.</ref> | |
| 68 | 71 | ||
| 69 | == See also == | 72 | == See also == |