Proglucagon: difference between revisions
Diff·revision 3 → 4·23:55, 28 Jul 2024
Difference between revision 3 and revision 4 of Proglucagon. 2 lines changed; the page grew by 370 bytes.
| Revision 3 — 12:32, 20 Jul 2024 ColdChainCleo (talk) space between number and unit per PP:MOS 1,868 bytes ±0 | Revision 4 — 23:55, 28 Jul 2024 DrTitration (talk) add the cleavage site by residue number 2,238 bytes +370 | ||
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| 13 | ''GCG'' lies on human chromosome 2 and comprises six exons. A single mRNA species is produced in all expressing tissues; there is no tissue-specific splicing in humans. Translation yields preproglucagon of 180 residues, from which the 20-residue signal peptide is removed co-translationally to give the 160-residue prohormone.{{r|sandoval2015}} | 13 | ''GCG'' lies on human chromosome 2 and comprises six exons. A single mRNA species is produced in all expressing tissues; there is no tissue-specific splicing in humans. Translation yields preproglucagon of 180 residues, from which the 20-residue signal peptide is removed co-translationally to give the 160-residue prohormone.{{r|sandoval2015}} |
| 14 | 14 | ||
| + | 15 | Transcription in the alpha cell is suppressed by insulin and by glucose, and stimulated during fasting — the arrangement expected of a counter-regulatory hormone. In the L cell, transcription responds instead to luminal nutrients and to short-chain fatty acids produced by colonic fermentation, and is comparatively insensitive to circulating glucose.{{r|holst2007}} | |
| + | 16 | ||
| 15 | == References == | 17 | == References == |
| 16 | {{reflist}} | 18 | {{reflist}} |