Liquid chromatography-mass spectrometry (revision 1)
Old revision·17:54, 18 Sep 2024·MassSpecMarv
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| Liquid chromatography-mass spectrometry | |
|---|---|
| Abbreviation | LC-MS |
| Combines | Chromatographic separation and mass detection |
| Interface | Usually electrospray |
| Adds | Identity to a retention-based separation |
| Analytical method infobox · conventions | |
Liquid chromatography-mass spectrometry couples a chromatographic separation to a mass spectrometer, so that each eluting peak is characterised by both its retention time and its mass. It converts a weak identification into a strong one.[1]
The interface is almost always electrospray, which works directly from flowing solution. This compatibility is what made the technique routine, and it constrains the chromatography: mobile phases must be volatile and free of non-volatile buffers.[2]
References
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