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Glossary of peptide terminology (revision 2)

Old revision·13:59, 21 Jul 2024·ReaderRosalie

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Glossary of peptide terminology
ScopeTerms used across this wiki
ArrangementBy domain, then alphabetically
List infobox · conventions

This glossary defines terms used across PeptidePedia Wiki. Each entry gives a short definition and, where a full article exists, links to it. Terms are grouped by domain and ordered alphabetically within each group.[1]

Definitions here are deliberately brief. Where a term carries a distinction that matters — purity against content, sterility against endotoxin freedom, contraindication against warning — the entry states the distinction and the article develops it.[2]

Chemistry and manufacture

[edit]
Aib
α-aminoisobutyric acid, a non-proteinogenic residue used to block DPP-4 cleavage.
Acylation
Attachment of a fatty acid to a peptide, usually for albumin binding.
Crude
The material obtained directly after cleavage, before purification. See Crude peptide.
Deletion sequence
A synthesis by-product missing one or more residues.
Fmoc
The base-labile temporary protecting group scheme dominating peptide synthesis.
Linker
The resin attachment defining the C-terminal functionality of the finished peptide.
Lyophilisation
Freeze-drying; the isolation step producing the powder in a vial. See Lyophilisation.
SPPS
Assembly of a peptide on an insoluble support.
TFA salt
The salt form in which most reverse-phase-purified peptides are isolated.[1]

References

  1. ^ a b United States Pharmacopeia, General Chapter <1503>, Quality Attributes of Synthetic Peptide Drug Substances.
  2. ^ United States Pharmacopeia, General Chapter <621>, Chromatography.