Enteroendocrine L cell: difference between revisions
Diff·revision 24 → 25·06:00, 29 Dec 2024
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| Revision 24 — 17:05, 19 Dec 2024 ProglucagonPia (talk) add category 3,466 bytes ±0 | Revision 25 — 06:00, 29 Dec 2024 GIP_Genoveva (talk) fix arithmetic in worked example 4,107 bytes +641 | ||
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| 15 | Once secreted, GLP-1 enters the portal blood and is rapidly inactivated by [[Dipeptidyl peptidase-4]] (DPP-4), which cleaves the N-terminal dipeptide. This short plasma half-life of 1–2 minutes is why GLP-1-directed drugs use either DPP-4 inhibitors or engineered peptides resistant to DPP-4 cleavage. | 15 | Once secreted, GLP-1 enters the portal blood and is rapidly inactivated by [[Dipeptidyl peptidase-4]] (DPP-4), which cleaves the N-terminal dipeptide. This short plasma half-life of 1–2 minutes is why GLP-1-directed drugs use either DPP-4 inhibitors or engineered peptides resistant to DPP-4 cleavage. |
| 16 | 16 | ||
| + | 17 | == L-cell plasticity and regulation == | |
| + | 18 | L-cell mass increases in response to elevated nutrient load, particularly in the weeks following bariatric surgery, indicating L cells are responsive to systemic metabolic signals.{{r|creutzfeldt1979}} Animal studies show that genetically obese mice have altered L-cell GLP-1 content and secretory response to nutrient stimuli; however, the corresponding relationship in humans remains incompletely characterised.{{r|furness2013}} | |
| + | 19 | ||
| 17 | == References == | 20 | == References == |
| 18 | {{reflist}} | 21 | {{reflist}} |
| 19 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). DOI:10.1152/physrev.00034.2006. PMID 17928588.</ref> | 22 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). DOI:10.1152/physrev.00034.2006. PMID 17928588.</ref> |
| 20 | <ref name="furness2013">Furness JB, Rivera LR, Cho H-J, Bravo DM, Callaghan B. "The gut as a sensory organ." ''Nature Reviews Gastroenterology & Hepatology'' 10(12):729–740 (2013). DOI:10.1038/nrgastro.2013.180. PMID 24061205.</ref> | 23 | <ref name="furness2013">Furness JB, Rivera LR, Cho H-J, Bravo DM, Callaghan B. "The gut as a sensory organ." ''Nature Reviews Gastroenterology & Hepatology'' 10(12):729–740 (2013). DOI:10.1038/nrgastro.2013.180. PMID 24061205.</ref> |
| + | 24 | <ref name="creutzfeldt1979">Creutzfeldt W, Ebert R, Willms B. "Gastro-intestinal peptide hormones and insulin secretion." ''Diabetologia'' 20 Suppl:85–98 (1979).</ref> | |
| 21 | 25 | ||
| 22 | == See also == | 26 | == See also == |