Enteroendocrine L cell: difference between revisions
Diff·revision 1 → 2·17:46, 6 Jul 2024
Difference between revision 1 and revision 2 of Enteroendocrine L cell. 3 lines changed; the page grew by 524 bytes.
| Revision 1 — 02:59, 4 Jul 2024 PriorAuthPaz (talk) start article 1,379 bytes +1,379 | Revision 2 — 17:46, 6 Jul 2024 MazdutideMads (talk) restructure 1,903 bytes +524 | ||
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| 3 | L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r|furness2013}} | 3 | L cells are open-type endocrine cells — their apical surface is exposed directly to the intestinal lumen, allowing direct contact with nutrients and bacterial metabolites. This arrangement is in contrast to closed-type endocrine cells, which do not face the lumen. The L-cell lineage differentiates from intestinal stem cells under the influence of specific transcription factors including neurogenic regulatory elements.{{r|furness2013}} |
| 4 | 4 | ||
| + | 5 | == Morphology and distribution == | |
| + | 6 | L cells are polarised epithelial cells with microvilli on the apical surface and secretory granules in the basolateral cytoplasm. The apical surface, open to the lumen, serves as the nutrient-sensing compartment; the basolateral surface contains receptors and ion channels that relay signals to the secretory machinery. L cells represent approximately 0.5–1% of all intestinal epithelial cells overall but are far more frequent in the ileum and colon than the duodenum.{{r|furness2013}} | |
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| 5 | == References == | 8 | == References == |
| 6 | {{reflist}} | 9 | {{reflist}} |