Enteroendocrine L cell: difference between revisions
Diff·revision 16 → 17·10:51, 13 Oct 2024
Difference between revision 16 and revision 17 of Enteroendocrine L cell. 2 lines changed; the page grew by 305 bytes.
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| 13 | [[Proglucagon]], the precursor peptide, is expressed in L cells and processed post-translationally to generate GLP-1. Secretion is triggered by nutrient ingestion and follows a biphasic time course: an early phase (10–15 minutes) mediated by neural and hormonal signals from the proximal gut, and a later phase (30–120 minutes) as nutrients reach the distal intestine.{{r|holst2007}} | 13 | [[Proglucagon]], the precursor peptide, is expressed in L cells and processed post-translationally to generate GLP-1. Secretion is triggered by nutrient ingestion and follows a biphasic time course: an early phase (10–15 minutes) mediated by neural and hormonal signals from the proximal gut, and a later phase (30–120 minutes) as nutrients reach the distal intestine.{{r|holst2007}} |
| 14 | 14 | ||
| + | 15 | Once secreted, GLP-1 enters the portal blood and is rapidly inactivated by [[Dipeptidyl peptidase-4]] (DPP-4), which cleaves the N-terminal dipeptide. This short plasma half-life of 1–2 minutes is why GLP-1-directed drugs use either DPP-4 inhibitors or engineered peptides resistant to DPP-4 cleavage. | |
| + | 16 | ||
| 15 | == References == | 17 | == References == |
| 16 | {{reflist}} | 18 | {{reflist}} |