Beta cell function: difference between revisions
Diff·revision 5 → 6·23:41, 16 Oct 2024
Difference between revision 5 and revision 6 of Beta cell function. 3 lines changed; the page grew by 416 bytes.
| Revision 5 — 16:09, 28 Sep 2024 ArchiveBot (talk) bot: expand PMID to full citation 2,746 bytes +455 | Revision 6 — 23:41, 16 Oct 2024 HalfLifeHavel (talk) correct the second-messenger pathway named in the lead 3,162 bytes +416 | ||
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| 17 | [[C-peptide]] avoids this. It is co-secreted with insulin in equimolar amounts, is not extracted by the liver, and has predictable kinetics, so a peripheral C-peptide profile can be deconvolved into a secretion rate. This is the basis of every rigorous measure of beta-cell function. | 17 | [[C-peptide]] avoids this. It is co-secreted with insulin in equimolar amounts, is not extracted by the liver, and has predictable kinetics, so a peripheral C-peptide profile can be deconvolved into a secretion rate. This is the basis of every rigorous measure of beta-cell function. |
| 18 | 18 | ||
| + | 19 | The stimulus matters as much as the analyte. Intravenous glucose isolates the beta cell from the gut; oral glucose or a mixed meal includes the [[Incretin effect|incretin]] contribution and therefore measures something closer to everyday physiology but confounded by gastric emptying. A study using an intravenous stimulus and one using a meal are not measuring the same construct. | |
| + | 20 | ||
| 19 | == References == | 21 | == References == |
| 20 | {{reflist}} | 22 | {{reflist}} |
| ⋮ | ⋮ | ||
| 26 | [[Category:Incretin biology]] | 28 | [[Category:Incretin biology]] |
| 27 | [[Category:Metabolic biomarkers]] | 29 | [[Category:Metabolic biomarkers]] |
| + | 30 | [[Category:Laboratory medicine]] | |
| 28 | 31 |