Bacteriostatic water: difference between revisions
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| 15 | Inhibition is not immediate and not universal. Some organisms are more resistant than the challenge panel, and preservative efficacy falls with dilution — a preserved diluent added to a large volume of unpreserved liquid may fall below its effective concentration. | 15 | Inhibition is not immediate and not universal. Some organisms are more resistant than the challenge panel, and preservative efficacy falls with dilution — a preserved diluent added to a large volume of unpreserved liquid may fall below its effective concentration. |
| 16 | 16 | ||
| + | 17 | The preservative also does nothing about chemical degradation. A preserved solution remains subject to [[Deamidation|deamidation]], oxidation and [[Peptide aggregation|aggregation]], and the presence of a preservative does not extend chemical stability at all.{{r|manning2010}} | |
| + | 18 | ||
| 17 | == References == | 19 | == References == |
| 18 | {{reflist}} | 20 | {{reflist}} |
| 19 | <ref name="usp51">United States Pharmacopeia, General Chapter <51>, ''Antimicrobial Effectiveness Testing''.</ref> | 21 | <ref name="usp51">United States Pharmacopeia, General Chapter <51>, ''Antimicrobial Effectiveness Testing''.</ref> |
| 20 | <ref name="usp797">United States Pharmacopeia, General Chapter <797>, ''Pharmaceutical Compounding — Sterile Preparations''.</ref> | 22 | <ref name="usp797">United States Pharmacopeia, General Chapter <797>, ''Pharmaceutical Compounding — Sterile Preparations''.</ref> |
| + | 23 | <ref name="manning2010">Manning MC, Chou DK, Murphy BM, Payne RW, Katayama DS. "Stability of protein pharmaceuticals: an update." ''Pharmaceutical Research'' 27(4):544–575 (2010). PMID 20143256.</ref> | |
| 21 | 24 | ||
| 22 | {{DEFAULTSORT:Bacteriostatic water}} | 25 | {{DEFAULTSORT:Bacteriostatic water}} |