Amylin: difference between revisions
Diff·revision 10 → 11·11:25, 20 Dec 2024
Difference between revision 10 and revision 11 of Amylin. 9 lines changed; the page grew by 456 bytes.
| Revision 10 — 18:40, 28 Nov 2024 DiffWatchDov (talk) close an unbalanced quotation mark 3,238 bytes ±0 | Revision 11 — 11:25, 20 Dec 2024 MazdutideMads (talk) add the receptor targets to the lead sentence 3,694 bytes +456 | ||
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| 24 | Because insulin and amylin are co-secreted, amylin deficiency accompanies insulin deficiency: in type 1 diabetes both are essentially absent, and this contributes to the exaggerated postprandial glucose excursions seen when insulin is replaced alone.{{r|hay2015,campbell2013}} | 24 | Because insulin and amylin are co-secreted, amylin deficiency accompanies insulin deficiency: in type 1 diabetes both are essentially absent, and this contributes to the exaggerated postprandial glucose excursions seen when insulin is replaced alone.{{r|hay2015,campbell2013}} |
| 25 | 25 | ||
| + | 26 | == Receptors == | |
| + | 27 | The amylin receptors are heterodimers of the calcitonin receptor with a RAMP. The RAMP does not merely traffic the receptor; it alters the ligand-binding pocket, converting a calcitonin receptor into one with high affinity for amylin. | |
| + | 28 | ||
| + | 29 | | Complex | Components | Note | | |
| + | 30 | |---|---|---| | |
| + | 31 | | AMY1 | CTR + RAMP1 | Highest amylin affinity; area postrema | | |
| + | 32 | | AMY2 | CTR + RAMP2 | Less well characterised | | |
| + | 33 | | AMY3 | CTR + RAMP3 | Widely distributed | | |
| + | 34 | ||
| 26 | == References == | 35 | == References == |
| 27 | {{reflist}} | 36 | {{reflist}} |