Vial: difference between revisions
Diff·revision 3 → 4·14:06, 30 Jul 2024
Difference between revision 3 and revision 4 of Vial. 3 lines changed; the page grew by 612 bytes.
| Revision 3 — 07:12, 28 Jul 2024 ParentCatPansy (talk) replace bare ref with full citation 3,311 bytes +38 | Revision 4 — 14:06, 30 Jul 2024 Areapercent_Ayo (talk) expand §Container closure integrity 3,923 bytes +612 | ||
|---|---|---|---|
| 19 | '''Moulded vials''' are formed by pressing molten glass in a mould. Walls are thicker and less uniform, tolerances looser, and the vials heavier and more robust. Moulding dominates for larger containers and where mechanical strength matters more than dimensional precision.{{r|iso8362_1}} | 19 | '''Moulded vials''' are formed by pressing molten glass in a mould. Walls are thicker and less uniform, tolerances looser, and the vials heavier and more robust. Moulding dominates for larger containers and where mechanical strength matters more than dimensional precision.{{r|iso8362_1}} |
| 20 | 20 | ||
| + | 21 | Polymer vials of cyclic olefin polymer or copolymer are established for products incompatible with glass or requiring extreme resistance to breakage. They eliminate delamination and alkali leaching, and they permit lower moisture-vapour barrier performance and different extractable profiles — trade-offs rather than improvements. Requirements for plastic packaging systems are set out in USP <661> and its subsidiary chapters.{{r|usp661}} | |
| + | 22 | ||
| 21 | == References == | 23 | == References == |
| 22 | {{reflist}} | 24 | {{reflist}} |
| + | 25 | <ref name="usp661">United States Pharmacopeia, General Chapter <661>, "Plastic Packaging Systems and Their Materials of Construction". USP–NF, current revision.</ref> | |
| 23 | <ref name="usp381">United States Pharmacopeia, General Chapter <381>, "Elastomeric Closures for Injections". USP–NF, current revision.</ref> | 26 | <ref name="usp381">United States Pharmacopeia, General Chapter <381>, "Elastomeric Closures for Injections". USP–NF, current revision.</ref> |
| 24 | <ref name="usp1207">United States Pharmacopeia, General Chapter <1207>, "Package Integrity Evaluation — Sterile Products" (informational), with subchapters <1207.1> to <1207.3>. USP–NF, current revision.</ref> | 27 | <ref name="usp1207">United States Pharmacopeia, General Chapter <1207>, "Package Integrity Evaluation — Sterile Products" (informational), with subchapters <1207.1> to <1207.3>. USP–NF, current revision.</ref> |