Temperature excursion: difference between revisions
Diff·revision 25 → 26·15:19, 17 Jul 2025
Difference between revision 25 and revision 26 of Temperature excursion. 4 lines changed; the page grew by 182 bytes.
| Revision 25 — 00:52, 14 Jul 2025 CouplingCillian (talk) add hatnote 12,027 bytes +262 | Revision 26 — 15:19, 17 Jul 2025 CiteBot (talk) bot: flag bare reference 12,209 bytes +182 | ||
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| 62 | The corresponding position for lyophilised research peptides is that no such allowance exists in a documented form. Supplier storage statements are recommendations, and the periods sometimes quoted for ambient tolerance are not supported by an identifiable stability study. The physical argument for the robustness of a dry cake is set out at [[Lyophilisation]] and is a reason to expect tolerance, not a substitute for having measured it.{{r|ppexcursion}} | 62 | The corresponding position for lyophilised research peptides is that no such allowance exists in a documented form. Supplier storage statements are recommendations, and the periods sometimes quoted for ambient tolerance are not supported by an identifiable stability study. The physical argument for the robustness of a dry cake is set out at [[Lyophilisation]] and is a reason to expect tolerance, not a substitute for having measured it.{{r|ppexcursion}} |
| 63 | 63 | ||
| + | 64 | {{seealso|Cold chain|Peptide stability table}} | |
| + | 65 | ||
| 64 | == Quantifying an excursion == | 66 | == Quantifying an excursion == |
| 65 | Where an excursion consists of warming, its cumulative effect is summarised by the mean kinetic temperature. For intervals of duration ''t''<sub>i</sub> at absolute temperatures ''T''<sub>i</sub>: | 67 | Where an excursion consists of warming, its cumulative effect is summarised by the mean kinetic temperature. For intervals of duration ''t''<sub>i</sub> at absolute temperatures ''T''<sub>i</sub>: |
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| 74 | 76 | ||
| 75 | {{math|(96 × 22 + 624 × 5) ÷ 720 = (2112 + 3120) ÷ 720 = 7.27 °C}} | 77 | {{math|(96 × 22 + 624 × 5) ÷ 720 = (2112 + 3120) ÷ 720 = 7.27 °C}} |
| + | 78 | ||
| + | 79 | which lies inside the labelled range. The mean kinetic temperature, however, weights by degradation. With T = 295.15 K and 278.15 K: | |
| 76 | 80 | ||
| 77 | == References == | 81 | == References == |