Syringe dead space: difference between revisions
Diff·revision 38 → 39·11:44, 22 Jan 2026
Difference between revision 38 and revision 39 of Syringe dead space. 6 lines changed; the page grew by 846 bytes.
| Revision 38 — 18:36, 17 Jan 2026 IncretinIvo (talk) split overlong sentence 17,673 bytes ±0 | Revision 39 — 11:44, 22 Jan 2026 TrialsTabitha (talk) fix unit 18,519 bytes +846 | ||
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| 131 | The practical consequence is that dead space must be measured or inferred rather than looked up. Published measurement follows a gravimetric protocol: the device is assembled, filled with water of known temperature, fully discharged against no back-pressure, and weighed before and after; the retained mass converted to volume gives the dead space. Reported precision is adequate to distinguish the device classes in the table above but not to distinguish nominally identical products from different manufacturers, where differences of 10–20 µL have been reported.{{r|zule2009}} | 131 | The practical consequence is that dead space must be measured or inferred rather than looked up. Published measurement follows a gravimetric protocol: the device is assembled, filled with water of known temperature, fully discharged against no back-pressure, and weighed before and after; the retained mass converted to volume gives the dead space. Reported precision is adequate to distinguish the device classes in the table above but not to distinguish nominally identical products from different manufacturers, where differences of 10–20 µL have been reported.{{r|zule2009}} |
| 132 | 132 | ||
| + | 133 | Because the parameter is undeclared, comparison between published studies requires care. Studies differ in whether the needle is included, whether the measurement is made with the plunger merely bottomed or forced, and whether back-pressure representative of tissue is applied. Values quoted without those details are not strictly comparable, and a difference between two published figures for the same device class is at least as likely to reflect protocol as product.{{r|bobashev2010}} | |
| + | 134 | ||
| 133 | == References == | 135 | == References == |
| 134 | {{reflist}} | 136 | {{reflist}} |
| ⋮ | ⋮ | ||
| 143 | <ref name="iso9626">ISO 9626:2016, ''Stainless steel needle tubing for the manufacture of medical devices — Requirements and test methods''. International Organization for Standardization.</ref> | 145 | <ref name="iso9626">ISO 9626:2016, ''Stainless steel needle tubing for the manufacture of medical devices — Requirements and test methods''. International Organization for Standardization.</ref> |
| 144 | <ref name="ppdeadspace">PeptidePedia community device-measurement tally, 2026 (self-reported, uncalibrated balances, protocol not controlled; weak evidence — see [[Project:Sourcing_guidelines]]).</ref> | 146 | <ref name="ppdeadspace">PeptidePedia community device-measurement tally, 2026 (self-reported, uncalibrated balances, protocol not controlled; weak evidence — see [[Project:Sourcing_guidelines]]).</ref> |
| + | 147 | ||
| + | 148 | == Further reading == | |
| + | 149 | * World Health Organization and UNAIDS. ''Technical Brief: Low Dead Space Syringes'' — the public-health framing of the parameter. | |
| + | 150 | * Frid AH, Kreugel G, Grassi G, et al. "New insulin delivery recommendations." ''Mayo Clinic Proceedings'' 91(9):1231–1255 (2016) — needle length and technique, with dead space treated in passing. | |
| 145 | 151 | ||
| 146 | == See also == | 152 | == See also == |