Subcutaneous injection (revision 1)
Old revision·09:00, 4 Aug 2024·LabRangeLindy
This is an old revision of this page, as it stood at 09:00, 4 Aug 2024, saved by LabRangeLindy with the summary new article: dosing and handling, expansion welcome. It may differ substantially from the current revision, and any error it contains may since have been corrected.
| Subcutaneous injection | |
|---|---|
| Abbreviation | SC, subQ |
| Target tissue | Subcutaneous adipose layer |
| Absorption | Slower and more sustained than intramuscular |
| Volume limit | Usually under 1.5 mL per site |
| Analytical method infobox · conventions | |
Subcutaneous injection delivers a substance into the adipose layer beneath the dermis. Absorption from this compartment is slower and more sustained than from muscle, because the tissue is less vascular, and it is the route used for almost every peptide therapeutic that is not given orally.[1]
The route suits peptides for two reasons. Absorption is largely by capillary and lymphatic uptake, which handles large molecules that would be destroyed in the gut; and the depot behaviour of the tissue smooths the concentration profile, which is desirable for a drug intended to act over days.[2]
References
- ^ American Diabetes Association. "Facilitating positive health behaviors and well-being to improve health outcomes: Standards of Care in Diabetes." Diabetes Care 47(Suppl 1) (2024).
- ^ Richter WF, Bhansali SG, Morris ME. "Mechanistic determinants of biotherapeutics absorption following SC administration." The AAPS Journal 14(3):559–570 (2012). DOI:10.1208/s12248-012-9367-0. PMID 22619043.
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