Subcutaneous injection: difference between revisions
Diff·revision 14 → 15·09:35, 21 Jan 2025
Difference between revision 14 and revision 15 of Subcutaneous injection. 2 lines changed; the page grew by 194 bytes.
| Revision 14 — 18:27, 5 Jan 2025 GramsNotUnitsGil (talk) add the disclaimer that this is not administration guidance 3,845 bytes +115 | Revision 15 — 09:35, 21 Jan 2025 SelectTrialSam (talk) add the note that a smaller diluent volume raises concentration, not dose 4,039 bytes +194 | ||
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| 32 | Differences of this kind are established for insulin and are commonly extrapolated to other subcutaneous preparations. The extrapolation is reasonable but is an extrapolation: for a peptide whose absorption half-life is long relative to its elimination half-life, site differences are absorbed into the profile and become clinically undetectable.{{r|richter2012}} | 32 | Differences of this kind are established for insulin and are commonly extrapolated to other subcutaneous preparations. The extrapolation is reasonable but is an extrapolation: for a peptide whose absorption half-life is long relative to its elimination half-life, site differences are absorbed into the profile and become clinically undetectable.{{r|richter2012}} |
| 33 | 33 | ||
| + | 34 | Local blood flow modifies all of these. Heat, exercise and massage increase it; cold reduces it. These effects are largest for preparations whose absorption is fast to begin with.{{r|ada2024}} | |
| + | 35 | ||
| 34 | == References == | 36 | == References == |
| 35 | {{reflist}} | 37 | {{reflist}} |