Satiety signalling: difference between revisions
Diff·revision 5 → 6·18:04, 14 Oct 2024
Difference between revision 5 and revision 6 of Satiety signalling. 3 lines changed; the page grew by 488 bytes.
| Revision 5 — 16:34, 27 Sep 2024 RepackRadek (talk) add the enteroendocrine cell type responsible for secretion 2,746 bytes +576 | Revision 6 — 18:04, 14 Oct 2024 LabRangeLindy (talk) correct the second-messenger pathway named in the lead 3,234 bytes +488 | ||
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| 17 | Intestinal hormones add nutrient specificity. Cholecystokinin is released from duodenal I cells in response to fat and protein and acts largely within a meal. GLP-1 and peptide YY are released from more distal [[Enteroendocrine L cell|L cells]] and act over a longer window. Amylin, co-secreted with insulin from the pancreas, acts at the area postrema.{{r|holst2007}} | 17 | Intestinal hormones add nutrient specificity. Cholecystokinin is released from duodenal I cells in response to fat and protein and acts largely within a meal. GLP-1 and peptide YY are released from more distal [[Enteroendocrine L cell|L cells]] and act over a longer window. Amylin, co-secreted with insulin from the pancreas, acts at the area postrema.{{r|holst2007}} |
| 18 | 18 | ||
| + | 19 | Adiposity signals set the background against which meal-related signals are read. Leptin and insulin circulate in proportion to fat mass and modulate the sensitivity of the hypothalamic circuits to meal-related input rather than terminating meals themselves.{{r|schwartz2000}} | |
| + | 20 | ||
| 19 | == References == | 21 | == References == |
| 20 | {{reflist}} | 22 | {{reflist}} |
| 21 | <ref name="woods2009">Woods SC. "The control of food intake: behavioral versus molecular perspectives." ''Cell Metabolism'' 9(6):489–498 (2009). DOI:10.1016/j.cmet.2009.04.007. PMID 19490904.</ref> | 23 | <ref name="woods2009">Woods SC. "The control of food intake: behavioral versus molecular perspectives." ''Cell Metabolism'' 9(6):489–498 (2009). DOI:10.1016/j.cmet.2009.04.007. PMID 19490904.</ref> |
| + | 24 | <ref name="schwartz2000">Schwartz MW, Woods SC, Porte D, Seeley RJ, Baskin DG. "Central nervous system control of food intake." ''Nature'' 404(6778):661–671 (2000). DOI:10.1038/35007534. PMID 10766253.</ref> | |
| 22 | <ref name="drucker2018">Drucker DJ. "Mechanisms of action and therapeutic application of glucagon-like peptide-1." ''Cell Metabolism'' 27(4):740–756 (2018). PMID 29617641.</ref> | 25 | <ref name="drucker2018">Drucker DJ. "Mechanisms of action and therapeutic application of glucagon-like peptide-1." ''Cell Metabolism'' 27(4):740–756 (2018). PMID 29617641.</ref> |
| 23 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). PMID 17928588.</ref> | 26 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). PMID 17928588.</ref> |