Satiety signalling: difference between revisions
Diff·revision 15 → 16·17:11, 17 Jun 2025
Difference between revision 15 and revision 16 of Satiety signalling. 5 lines changed; the page grew by 775 bytes.
| Revision 15 — 12:03, 13 May 2025 Hedgerow_Hal (talk) rm the causal claim about appetite — the cited work is associative 4,470 bytes +29 | Revision 16 — 17:11, 17 Jun 2025 CategoryBot (talk) bot: expand PMID to full citation 5,245 bytes +775 | ||
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| 27 | Brainstem and hypothalamic circuits are interconnected and partly redundant. Brainstem circuits alone are sufficient for meal termination in decerebrate animal preparations, whereas hypothalamic circuits carry the longer-term adiposity signal — one reason acute satiation and chronic body-weight regulation can be dissociated pharmacologically.{{r|woods2009}} | 27 | Brainstem and hypothalamic circuits are interconnected and partly redundant. Brainstem circuits alone are sufficient for meal termination in decerebrate animal preparations, whereas hypothalamic circuits carry the longer-term adiposity signal — one reason acute satiation and chronic body-weight regulation can be dissociated pharmacologically.{{r|woods2009}} |
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| + | 29 | == Why pharmacological agonism differs from physiology == | |
| + | 30 | Endogenous GLP-1 is secreted episodically, is degraded within minutes by [[Dipeptidyl peptidase-4|DPP-4]], and acts substantially through vagal afferents in the intestinal wall before reaching the systemic circulation. A weekly agonist produces a continuous circulating concentration far above the physiological range and acts predominantly at central sites reachable from the blood.{{r|drucker2018}} | |
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| + | 32 | This is why the pharmacology does not simply amplify the physiology. The nausea that accompanies agonist therapy reflects area postrema engagement that endogenous secretion does not produce at comparable intensity, and the sustained reduction in food intake reflects continuous rather than meal-linked signalling. | |
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| 29 | == References == | 34 | == References == |
| 30 | {{reflist}} | 35 | {{reflist}} |