STEP trial programme: difference between revisions
Diff·revision 14 → 15·10:28, 25 Jan 2025
Difference between revision 14 and revision 15 of STEP trial programme. 2 lines changed; the page grew by 293 bytes.
| Revision 14 — 17:19, 7 Jan 2025 Hedgerow_Hal (talk) expand §Design features that shape the figures 4,064 bytes ±0 | Revision 15 — 10:28, 25 Jan 2025 ToleranceTove (talk) correct the baseline mean — transposed digits 4,357 bytes +293 | ||
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| 34 | Both arms received lifestyle intervention — reduced-calorie diet and increased physical activity, with regular counselling. This is standard for obesity trials and it raises the placebo arm, which is why placebo-arm weight change in these trials is not zero. | 34 | Both arms received lifestyle intervention — reduced-calorie diet and increased physical activity, with regular counselling. This is standard for obesity trials and it raises the placebo arm, which is why placebo-arm weight change in these trials is not zero. |
| 35 | 35 | ||
| + | 36 | Analysis populations matter. The primary estimand in several of these trials treats data after treatment discontinuation in a defined way, and the "treatment policy" and "trial product" estimands give different numbers from the same data. See [[Intention-to-treat analysis]].{{r|davies2021}} | |
| + | 37 | ||
| 36 | == References == | 38 | == References == |
| 37 | {{reflist}} | 39 | {{reflist}} |