Residual solvent: difference between revisions
Diff·revision 12 → 13·11:14, 19 Mar 2025
Difference between revision 12 and revision 13 of Residual solvent. 2 lines changed; the page grew by 389 bytes.
| Revision 12 — 20:14, 19 Feb 2025 KarlFischerKit (talk) add the peptide-content point: area percent alone cannot give a mass 3,736 bytes ±0 | Revision 13 — 11:14, 19 Mar 2025 CategoryBot (talk) bot: repair redlinked category 4,125 bytes +389 | ||
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| 29 | A certificate reporting "residual solvents: conforms" is therefore reporting conformity with respect to whichever solvents were in the method. A certificate itemising the solvents tested, with a result for each, is a substantially stronger document — the same argument that applies to itemised related substances at [[Limit of detection]]. | 29 | A certificate reporting "residual solvents: conforms" is therefore reporting conformity with respect to whichever solvents were in the method. A certificate itemising the solvents tested, with a result for each, is a substantially stronger document — the same argument that applies to itemised related substances at [[Limit of detection]]. |
| 30 | 30 | ||
| + | 31 | Trifluoroacetic acid is a special case. It is used in both cleavage and purification, is not always covered by a standard residual-solvent method, and in the isolated peptide is present largely as the [[Trifluoroacetate counterion|trifluoroacetate counterion]] rather than as free acid. The counterion is determined by a separate ion-chromatographic or spectroscopic method.{{r|usp1503}} | |
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| 31 | == References == | 33 | == References == |
| 32 | {{reflist}} | 34 | {{reflist}} |