Receptor bias: difference between revisions
Diff·revision 3 → 4·20:28, 9 Oct 2024
Difference between revision 3 and revision 4 of Receptor bias. 2 lines changed; the page grew by 167 bytes.
| Revision 3 — 18:19, 28 Sep 2024 TalkPageTaro (talk) de-orphan 1,938 bytes ±0 | Revision 4 — 20:28, 9 Oct 2024 ProglucagonPia (talk) give the fasting and postprandial concentrations with the assay named 2,105 bytes +167 | ||
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| 15 | Quantification requires care because potency and efficacy differences that are not bias — receptor reserve differences between assays, for instance — can masquerade as it. Operational models exist to separate the two and their assumptions are not always met.{{r|kenakin2013}} | 15 | Quantification requires care because potency and efficacy differences that are not bias — receptor reserve differences between assays, for instance — can masquerade as it. Operational models exist to separate the two and their assumptions are not always met.{{r|kenakin2013}} |
| 16 | 16 | ||
| + | 17 | The concept is real and well supported at the level of receptor conformation. What is contested is whether measured bias predicts anything clinically.{{r|jones2018}} | |
| + | 18 | ||
| 17 | == References == | 19 | == References == |
| 18 | {{reflist}} | 20 | {{reflist}} |