Proglucagon: difference between revisions
Diff·revision 1 → 2·16:43, 9 Jul 2024
Difference between revision 1 and revision 2 of Proglucagon. 3 lines changed; the page grew by 372 bytes.
| Revision 1 — 09:00, 8 Jul 2024 Chromatokid (talk) new article: incretin physiology, expansion welcome 1,496 bytes +1,496 | Revision 2 — 16:43, 9 Jul 2024 TrialsTabitha (talk) add category for receptor pharmacology 1,868 bytes +372 | ||
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| 10 | The products differ between those tissues because the processing enzymes do. Prohormone convertase 2 predominates in the alpha cell and liberates glucagon; prohormone convertase 1/3 predominates in the L cell and the brainstem and liberates GLP-1 and GLP-2 instead. A single transcript therefore yields a hyperglycaemic hormone in one tissue and a hypoglycaemic one in another.{{r|holst2007}} | 10 | The products differ between those tissues because the processing enzymes do. Prohormone convertase 2 predominates in the alpha cell and liberates glucagon; prohormone convertase 1/3 predominates in the L cell and the brainstem and liberates GLP-1 and GLP-2 instead. A single transcript therefore yields a hyperglycaemic hormone in one tissue and a hypoglycaemic one in another.{{r|holst2007}} |
| 11 | 11 | ||
| + | 12 | == Gene and transcript == | |
| + | 13 | ''GCG'' lies on human chromosome 2 and comprises six exons. A single mRNA species is produced in all expressing tissues; there is no tissue-specific splicing in humans. Translation yields preproglucagon of 180 residues, from which the 20-residue signal peptide is removed co-translationally to give the 160-residue prohormone.{{r|sandoval2015}} | |
| + | 14 | ||
| 12 | == References == | 15 | == References == |
| 13 | {{reflist}} | 16 | {{reflist}} |