Proglucagon: difference between revisions
Diff·revision 12 → 13·10:39, 1 Dec 2024
Difference between revision 12 and revision 13 of Proglucagon. 3 lines changed; the page grew by 673 bytes.
| Revision 12 — 12:26, 15 Nov 2024 IncretinIvo (talk) close an unbalanced quotation mark 3,465 bytes +27 | Revision 13 — 10:39, 1 Dec 2024 COA_Colwyn (talk) add see also to the sister hormone 4,138 bytes +673 | ||
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| 33 | | Caudal brainstem | PC1/3 | GLP-1, GLP-2 | | 33 | | Caudal brainstem | PC1/3 | GLP-1, GLP-2 | |
| 34 | 34 | ||
| + | 35 | The boundaries are not absolute. Alpha cells upregulate PC1/3 under metabolic stress and can secrete GLP-1 directly, a phenomenon described in islets from donors with type 2 diabetes and in rodent models of beta-cell injury. The physiological importance of islet-derived GLP-1 in humans is debated; the quantities are small relative to intestinal secretion but are delivered locally, where concentration at the receptor may matter more than circulating concentration.{{r|campbell2013}} | |
| + | 36 | ||
| 35 | == References == | 37 | == References == |
| 36 | {{reflist}} | 38 | {{reflist}} |
| 37 | <ref name="sandoval2015">Sandoval DA, D'Alessio DA. "Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease." ''Physiological Reviews'' 95(2):513–548 (2015). DOI:10.1152/physrev.00013.2014. PMID 25834231.</ref> | 39 | <ref name="sandoval2015">Sandoval DA, D'Alessio DA. "Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease." ''Physiological Reviews'' 95(2):513–548 (2015). DOI:10.1152/physrev.00013.2014. PMID 25834231.</ref> |
| 38 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). PMID 17928588.</ref> | 40 | <ref name="holst2007">Holst JJ. "The physiology of glucagon-like peptide 1." ''Physiological Reviews'' 87(4):1409–1439 (2007). PMID 17928588.</ref> |
| + | 41 | <ref name="campbell2013">Campbell JE, Drucker DJ. "Pharmacology, physiology, and mechanisms of incretin hormone action." ''Cell Metabolism'' 17(6):819–837 (2013). PMID 23684623.</ref> | |
| 39 | 42 | ||
| 40 | {{DEFAULTSORT:Proglucagon}} | 43 | {{DEFAULTSORT:Proglucagon}} |