Proglucagon: difference between revisions
Diff·revision 10 → 11·09:06, 29 Oct 2024
Difference between revision 10 and revision 11 of Proglucagon. 9 lines changed; the page grew by 363 bytes.
| Revision 10 — 06:42, 9 Oct 2024 ReceptorRhoda (talk) rm a duplicated category 3,075 bytes ±0 | Revision 11 — 09:06, 29 Oct 2024 GsCouplingGil (talk) consistent en dashes in ranges 3,438 bytes +363 | ||
|---|---|---|---|
| 23 | Transcription in the alpha cell is suppressed by insulin and by glucose, and stimulated during fasting — the arrangement expected of a counter-regulatory hormone. In the L cell, transcription responds instead to luminal nutrients and to short-chain fatty acids produced by colonic fermentation, and is comparatively insensitive to circulating glucose.{{r|holst2007}} | 23 | Transcription in the alpha cell is suppressed by insulin and by glucose, and stimulated during fasting — the arrangement expected of a counter-regulatory hormone. In the L cell, transcription responds instead to luminal nutrients and to short-chain fatty acids produced by colonic fermentation, and is comparatively insensitive to circulating glucose.{{r|holst2007}} |
| 24 | 24 | ||
| + | 25 | == Tissue-specific processing == | |
| + | 26 | Processing is directed by which prohormone convertase is expressed. | |
| + | 27 | ||
| + | 28 | | Tissue | Dominant convertase | Principal products | | |
| + | 29 | |---|---|---| | |
| + | 30 | | Pancreatic alpha cell | PC2 | Glucagon, GRPP, major proglucagon fragment | | |
| + | 31 | | Intestinal L cell | PC1/3 | GLP-1, GLP-2, oxyntomodulin, glicentin | | |
| + | 32 | | Caudal brainstem | PC1/3 | GLP-1, GLP-2 | | |
| + | 33 | ||
| 25 | == References == | 34 | == References == |
| 26 | {{reflist}} | 35 | {{reflist}} |