Placebo-adjusted effect (revision 1)
Old revision·09:00, 7 Oct 2024·DiagramDelphine
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| Placebo-adjusted effect | |
|---|---|
| Also called | Between-group difference, treatment difference |
| Computed as | Active-arm change minus placebo-arm change |
| Why it matters | The active-arm change alone is not the drug effect |
| Topic infobox · conventions | |
The placebo-adjusted effect is the difference between the change observed in a treatment arm and the change observed in the comparator arm. It is the quantity a randomised trial is designed to estimate, and it is what can be attributed to the treatment.[1]
The active-arm change alone conflates the treatment effect with everything else operating during the trial: regression to the mean, the natural course of the condition, the lifestyle intervention both arms received, and the effects of being observed.[2]
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