Peptide synthesis: difference between revisions
Diff·revision 15 → 16·23:29, 15 Jan 2025
Difference between revision 15 and revision 16 of Peptide synthesis. 2 lines changed; the page grew by 332 bytes.
| Revision 15 — 06:21, 27 Dec 2024 CostPerMgCory (talk) space between number and unit per PP:MOS 3,781 bytes +31 | Revision 16 — 23:29, 15 Jan 2025 ArchiveBot (talk) bot: sort category members 4,113 bytes +332 | ||
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| 28 | The material lost is not simply absent — it is present as truncated and deletion sequences, which remain attached to the support and are cleaved along with the target. These are the impurities that dominate a [[Crude peptide|crude]] peptide and that a purity method must resolve. | 28 | The material lost is not simply absent — it is present as truncated and deletion sequences, which remain attached to the support and are cleaved along with the target. These are the impurities that dominate a [[Crude peptide|crude]] peptide and that a purity method must resolve. |
| 29 | 29 | ||
| + | 30 | Difficult sequences make the arithmetic worse. Aggregation of the growing chain on the support hides the reactive terminus and depresses coupling yields locally, which is why particular regions of a sequence rather than the whole are usually responsible for a poor crude. See [[Solid-phase peptide synthesis]].{{r|merrifield1963}} | |
| + | 31 | ||
| 30 | == References == | 32 | == References == |
| 31 | {{reflist}} | 33 | {{reflist}} |