Number needed to treat: difference between revisions
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| 20 | The corresponding relative figure — a hazard ratio of 0.80, or a 20% relative reduction — is the same result expressed differently and sounds considerably larger. Neither is wrong; they are the same arithmetic.{{r|laupacis1988}} | 20 | The corresponding relative figure — a hazard ratio of 0.80, or a 20% relative reduction — is the same result expressed differently and sounds considerably larger. Neither is wrong; they are the same arithmetic.{{r|laupacis1988}} |
| 21 | 21 | ||
| + | 22 | Confidence intervals transfer awkwardly. The interval for a number needed to treat is the reciprocal of the interval for the absolute risk reduction, and it behaves badly when that interval spans zero, which is one reason the measure is best used for statistically significant results.{{r|altman1998}} | |
| + | 23 | ||
| 22 | == References == | 24 | == References == |
| 23 | {{reflist}} | 25 | {{reflist}} |
| 24 | <ref name="laupacis1988">Laupacis A, Sackett DL, Roberts RS. "An assessment of clinically useful measures of the consequences of treatment." ''New England Journal of Medicine'' 318(26):1728–1733 (1988). PMID 3374545.</ref> | 26 | <ref name="laupacis1988">Laupacis A, Sackett DL, Roberts RS. "An assessment of clinically useful measures of the consequences of treatment." ''New England Journal of Medicine'' 318(26):1728–1733 (1988). PMID 3374545.</ref> |
| + | 27 | <ref name="altman1998">Altman DG. "Confidence intervals for the number needed to treat." ''BMJ'' 317(7168):1309–1312 (1998). PMID 9804726.</ref> | |
| 25 | <ref name="lincoff2023">Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. "Semaglutide and cardiovascular outcomes in obesity without diabetes." ''New England Journal of Medicine'' 389(24):2221–2232 (2023). PMID 37952131.</ref> | 28 | <ref name="lincoff2023">Lincoff AM, Brown-Frandsen K, Colhoun HM, et al. "Semaglutide and cardiovascular outcomes in obesity without diabetes." ''New England Journal of Medicine'' 389(24):2221–2232 (2023). PMID 37952131.</ref> |
| 26 | 29 |