Missed dose: difference between revisions

Diff·revision 2 → 3·10:13, 17 Oct 2024

Difference between revision 2 and revision 3 of Missed dose. 10 lines changed; the page grew by 597 bytes.

Revision 2 — 20:01, 29 Sep 2024 MicrodoseMagnus (talk) add the note about drawing air before withdrawal 1,432 bytes ±0	Revision 3 — 10:13, 17 Oct 2024 Chromatokid (talk) add the preservative point: unpreserved diluent changes the interval 2,029 bytes +597
10	For a weekly agent with a half-life of several days, the concentration at the end of a normal dosing interval has fallen to a substantial fraction of its peak, and a missed week extends that decline rather than producing a sudden loss of exposure. For a daily agent with a half-life of hours, a missed day is a larger proportional change but is corrected within a day or two of resuming.{{r\|knudsen2019}}	10	For a weekly agent with a half-life of several days, the concentration at the end of a normal dosing interval has fallen to a substantial fraction of its peak, and a missed week extends that decline rather than producing a sudden loss of exposure. For a daily agent with a half-life of hours, a missed day is a larger proportional change but is corrected within a day or two of resuming.{{r\|knudsen2019}}
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+		12	== The governing arithmetic ==
+		13	After a dose, concentration falls by half each half-life. For a peptide with a half-life of seven days on a weekly schedule, trough concentration is about half the peak and steady-state accumulation is roughly two-fold. Omitting one dose allows a further halving before the next dose is taken.{{r\|knudsen2019}}
+		14
+		15	\| Half-life \| Interval \| Fall over one missed interval \|
+		16	\|---\|---\|---\|
+		17	\| ≈7 days \| Weekly \| To about half \|
+		18	\| ≈5 days \| Weekly \| To about two fifths \|
+		19	\| ≈13 hours \| Daily \| To a few per cent \|
+		20	\| ≈2.4 hours \| Twice daily \| Essentially complete \|
+		21
12	== References ==	22	== References ==
13	{{reflist}}	23	{{reflist}}