Melanotan II: difference between revisions
Diff·revision 10 → 11·15:30, 5 Apr 2025
Difference between revision 10 and revision 11 of Melanotan II. 7 lines changed; the page grew by 259 bytes.
| Revision 10 — 18:18, 16 Mar 2025 SchematicScout (talk) the sequence in the infobox was missing the C-terminal amide; added 3,391 bytes +33 | Revision 11 — 15:30, 5 Apr 2025 ThymosinTamsin (talk) give the counterion, since it changes the mass by several per cent 3,650 bytes +259 | ||
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| 26 | Dermatological effects are the more consequential. Darkening of existing naevi, appearance of new pigmented lesions, and eruptive naevi have been reported, and there are case reports of melanoma in users. Whether the compound is causal is unestablished: users are self-selected for sun exposure and tanning behaviour, and increased dermatological surveillance in a population that has changed colour will find more lesions.{{r|cardones2009}} | 26 | Dermatological effects are the more consequential. Darkening of existing naevi, appearance of new pigmented lesions, and eruptive naevi have been reported, and there are case reports of melanoma in users. Whether the compound is causal is unestablished: users are self-selected for sun exposure and tanning behaviour, and increased dermatological surveillance in a population that has changed colour will find more lesions.{{r|cardones2009}} |
| 27 | 27 | ||
| + | 28 | The honest position is that a mechanistic reason for concern exists — melanocyte stimulation — the case reports exist, and causation is not demonstrated.{{r|cardones2009}} | |
| + | 29 | ||
| 28 | == References == | 30 | == References == |
| 29 | {{reflist}} | 31 | {{reflist}} |
| ⋮ | ⋮ | ||
| 31 | <ref name="cardones2009">Cardones AR, Grichnik JM. "α-Melanocyte-stimulating hormone-induced eruptive nevi." ''Archives of Dermatology'' 145(4):441–444 (2009). PMID 19380667.</ref> | 33 | <ref name="cardones2009">Cardones AR, Grichnik JM. "α-Melanocyte-stimulating hormone-induced eruptive nevi." ''Archives of Dermatology'' 145(4):441–444 (2009). PMID 19380667.</ref> |
| 32 | <ref name="cone2005">Cone RD. "Anatomy and regulation of the central melanocortin system." ''Nature Neuroscience'' 8(5):571–578 (2005). PMID 15856065.</ref> | 34 | <ref name="cone2005">Cone RD. "Anatomy and regulation of the central melanocortin system." ''Nature Neuroscience'' 8(5):571–578 (2005). PMID 15856065.</ref> |
| + | 35 | ||
| + | 36 | == See also == | |
| + | 37 | * [[Bremelanotide]] | |
| + | 38 | * [[Arcuate nucleus]] | |
| + | 39 | * [[Research use only]] | |
| 33 | 40 | ||
| 34 | {{DEFAULTSORT:Melanotan II}} | 41 | {{DEFAULTSORT:Melanotan II}} |