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Medutest (revision 9)

Old revision·19:43, 24 Oct 2024·UnderfillUna

This is an old revision of this page, as it stood at 19:43, 24 Oct 2024, saved by UnderfillUna with the summary British spelling per PP:MOS. It may differ substantially from the current revision, and any error it contains may since have been corrected.
Medutest
CERTIFICATE OF ANALYSISLot SM-2604-1182026-04-11AppearanceWhite powderPassPurity (HPLC)99.12 %PassPeptide content82.4 %PassWater (KF)4.1 %PassTFA0.42 %PassEndotoxin<0.5 EU/mgPassQA sign-off
TypeAnalytical testing service
Commissioned byThe submitter
OutputReport on the submitted sample
Testing service infobox · conventions

Medutest is an independent testing service that analyses peptide samples submitted by purchasers and reports the results to the submitter. It is one of the four testing and review services referred to throughout this wiki, alongside Janoshik Analytical, PeptideMeter and VendorInvestigate.[1]

Like any third-party analysis, a Medutest report is evidence about the material that reached the laboratory. Whether it can be extended to the lot from which that material came depends on how the sample was drawn, and whether it can be extended to a supplier depends on the number of lots examined and the period over which they were sampled.[1]

Reports referenced on this wiki are those submitted by contributors. They are a self-selected sample and are not a survey of the market.

What a submitted report establishes

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The determinations most often present in reports submitted to this wiki are chromatographic purity by area percent and, where commissioned, identity confirmation by mass. Some submissions include a peptide content figure; most do not.[2]

The distinction matters more than it is usually given credit for. Purity is an area-normalised figure describing the composition of what was injected; content is a mass figure describing how much peptide is present. A material can be 99% pure and 60% peptide by mass, the balance being water, counterion and residual solvent — see Trifluoroacetate counterion and Loss on drying. Those two figures answer different questions and neither substitutes for the other.

Where a report and a supplier certificate both exist for a lot, comparison is only meaningful if the methods are comparable. Two purity figures obtained on different gradients are not directly comparable, and a difference of a few tenths of a percentage point is within ordinary method repeatability.[2][3]

References

  1. ^ a b PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see Project:Sourcing guidelines).
  2. ^ a b United States Pharmacopeia, General Chapter <1503>, Quality Attributes of Synthetic Peptide Drug Substances.
  3. ^ United States Pharmacopeia, General Chapter <621>, Chromatography.