MOTS-c: difference between revisions
Diff·revision 16 → 17·05:23, 14 Jul 2025
Difference between revision 16 and revision 17 of MOTS-c. 7 lines changed; the page grew by 839 bytes.
| Revision 16 — 18:42, 23 Jun 2025 GHK_Gwendolen (talk) label the secretagogue claim as receptor-level, not clinical 3,596 bytes ±0 | Revision 17 — 05:23, 14 Jul 2025 Chromatokid (talk) state the research-use-only status in the lead, not only in the footer 4,435 bytes +839 | ||
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| 29 | No adequately powered controlled trial of administration in humans has reported. The gap between the preclinical literature and the human evidence is wide, and it should not be closed by inference.{{r|lee2015}} | 29 | No adequately powered controlled trial of administration in humans has reported. The gap between the preclinical literature and the human evidence is wide, and it should not be closed by inference.{{r|lee2015}} |
| 30 | 30 | ||
| + | 31 | == Material in research supply == | |
| + | 32 | MOTS-c is offered by research-chemical suppliers. It is unapproved, and this wiki does not represent it as suitable for human use; see [[Research use only]].{{r|reports}} | |
| + | 33 | ||
| + | 34 | As a 16-residue peptide it is a straightforward synthesis relative to the incretin analogues, and the documentary considerations are the ordinary ones: identity by [[Mass spectrometry|mass]], purity by a named chromatographic method, and [[Peptide content|content]] with water and counterion if the mass of peptide in a vial is to be known.{{r|usp1503}} | |
| + | 35 | ||
| 31 | == References == | 36 | == References == |
| 32 | {{reflist}} | 37 | {{reflist}} |
| 33 | <ref name="lee2015">Lee C, Zeng J, Drew BG, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." ''Cell Metabolism'' 21(3):443–454 (2015). PMID 25738459.</ref> | 38 | <ref name="lee2015">Lee C, Zeng J, Drew BG, et al. "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance." ''Cell Metabolism'' 21(3):443–454 (2015). PMID 25738459.</ref> |
| 34 | <ref name="kim2018">Kim KH, Son JM, Benayoun BA, Lee C. "The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress." ''Cell Metabolism'' 28(3):516–524 (2018). PMID 29983246.</ref> | 39 | <ref name="kim2018">Kim KH, Son JM, Benayoun BA, Lee C. "The mitochondrial-encoded peptide MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress." ''Cell Metabolism'' 28(3):516–524 (2018). PMID 29983246.</ref> |
| + | 40 | <ref name="usp1503">United States Pharmacopeia, General Chapter <1503>, ''Quality Attributes of Synthetic Peptide Drug Substances''.</ref> | |
| + | 41 | <ref name="reports">PeptidePedia Wiki community test-report tally, 2024–2026 (self-reported; see [[Project:Sourcing_guidelines]]).</ref> | |
| 35 | 42 | ||
| 36 | == See also == | 43 | == See also == |