Loss on drying (revision 2)
Old revision·14:50, 21 Aug 2024·ConsensusConal
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| Loss on drying | |
|---|---|
| Abbreviation | LOD |
| Measures | Total volatile mass lost under defined conditions |
| Contrast with | Karl Fischer titration, which measures water specifically |
| Compendial chapter | USP <731> |
| Analytical method infobox · conventions | |
Loss on drying determines the mass a sample loses when heated under defined conditions of temperature, pressure and time. It is simple, requires no specialised reagent, and is widely reported on peptide certificates.[1]
It is not a water determination. The mass lost comprises water and any other volatile component — residual acetonitrile, acetic acid, ammonia from a salt-exchange step — so a loss-on-drying figure is an upper bound on water content rather than a measurement of it. Karl Fischer titration measures water specifically and will generally give a lower number on the same material.[2]
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