Insulin secretion: difference between revisions
Diff·revision 12 → 13·11:19, 19 Feb 2025
Difference between revision 12 and revision 13 of Insulin secretion. 5 lines changed; the page grew by 887 bytes.
| Revision 12 — 15:46, 19 Jan 2025 ArchiveBot (talk) bot: update parent category chain 4,555 bytes ±0 | Revision 13 — 11:19, 19 Feb 2025 DPP4_Dagmar (talk) add the reference range with the assay it was established on 5,442 bytes +887 | ||
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| 29 | Amino acids, free fatty acids acting at FFAR1, and parasympathetic input all amplify. The [[Incretin effect|incretin effect]] — the excess of the oral over the intravenous insulin response — is the integrated ''in vivo'' expression of the hormonal amplifiers.{{r|campbell2013}} | 29 | Amino acids, free fatty acids acting at FFAR1, and parasympathetic input all amplify. The [[Incretin effect|incretin effect]] — the excess of the oral over the intravenous insulin response — is the integrated ''in vivo'' expression of the hormonal amplifiers.{{r|campbell2013}} |
| 30 | 30 | ||
| + | 31 | == Pulsatility and measurement == | |
| + | 32 | Insulin is secreted in pulses of five to ten minutes' period, superimposed on the biphasic pattern. Pulsatility is degraded early in type 2 diabetes and in first-degree relatives of affected people. Because the liver extracts insulin in a pulse-dependent manner, degraded pulsatility alters hepatic insulin exposure disproportionately to any change in mean concentration.{{r|rorsman2013}} | |
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| + | 34 | Secretion is measured indirectly. Peripheral insulin concentration understates secretion because of first-pass hepatic extraction, so [[C-peptide]] — co-secreted equimolar with insulin and not extracted by the liver — is the preferred analyte for quantifying secretory rate. Deconvolution of C-peptide kinetics gives a secretion profile; simpler indices such as HOMA-B and the insulinogenic index are cruder but require only a fasting or a two-point sample. | |
| + | 35 | ||
| 31 | == References == | 36 | == References == |
| 32 | {{reflist}} | 37 | {{reflist}} |