Injection site rotation (revision 1)
Old revision·19:51, 10 Sep 2024·FlowTrialFraser
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| Injection site rotation | |
|---|---|
| Problem addressed | Lipohypertrophy and erratic absorption |
| Within-region rotation | Preserves regional absorption characteristics |
| Between-region rotation | Changes absorption characteristics as well |
| Topic infobox · conventions | |
Injection site rotation is the practice of varying the location of successive subcutaneous injections. Its purpose is to avoid the local tissue changes that repeated injection at one point produces, principally lipohypertrophy — a thickening of the subcutaneous tissue from which absorption becomes erratic.[1]
The evidence base is largely from insulin therapy, where lipohypertrophy is common, is associated with unpredictable glycaemic control, and resolves slowly when the affected area is rested. Its relevance to weekly peptide administration is less well characterised, since injection frequency is roughly one seventh of that in basal-bolus insulin therapy.[2]
References
- ^ American Diabetes Association. "Facilitating positive health behaviors and well-being to improve health outcomes: Standards of Care in Diabetes." Diabetes Care 47(Suppl 1) (2024).
- ^ Gentile S, Strollo F, Ceriello A. "Lipodystrophy in insulin-treated subjects and other injection-site skin reactions: are we sure everything is clear?" Diabetes Therapy 7(3):401–409 (2016). PMID 27503118.
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