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Hypoglycaemia (revision 1)

Old revision·18:02, 6 Aug 2024·CrudePeptidePearl

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Hypoglycaemia
Common thresholdBelow 3.9 mmol/L (70 mg/dL)
Level 2Below 3.0 mmol/L (54 mg/dL)
Level 3Severe: requires assistance
Risk with incretin monotherapyLow
Topic infobox · conventions

Hypoglycaemia is abnormally low blood glucose. It is classified by level: below 3.9 mmol/L as an alert value, below 3.0 mmol/L as clinically significant, and any episode requiring assistance as severe regardless of the measured value.[1]

Incretin agonists carry a low intrinsic risk because their action on insulin secretion is glucose-dependent: they amplify a response that glucose has initiated rather than initiating one. Below the glucose threshold for triggering, there is nothing to amplify.[2]

References

  1. ^ American Diabetes Association. "Standards of Care in Diabetes." Diabetes Care 47(Suppl 1) (2024).
  2. ^ Nauck MA, Meier JJ. "The incretin effect in healthy individuals and those with type 2 diabetes." The Lancet Diabetes & Endocrinology 4(6):525–536 (2016). PMID 26876794.