HOMA-IR: difference between revisions
Diff·revision 8 → 9·23:21, 1 Jan 2025
Difference between revision 8 and revision 9 of HOMA-IR. 11 lines changed; the page grew by 681 bytes.
| Revision 8 — 15:19, 16 Dec 2024 PriorAuthPaz (talk) rm the diagnostic threshold — the article describes, it does not diagnose 2,497 bytes ±0 | Revision 9 — 23:21, 1 Jan 2025 EndpointEnid (talk) add the cross-link to the organ-function article 3,178 bytes +681 | ||
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| 23 | Both forms assume steady-state fasting conditions, and neither has a meaning in anyone receiving exogenous insulin, since the insulin measured is then not the beta cell's output. | 23 | Both forms assume steady-state fasting conditions, and neither has a meaning in anyone receiving exogenous insulin, since the insulin measured is then not the beta cell's output. |
| 24 | 24 | ||
| + | 25 | == What it does and does not measure == | |
| + | 26 | | Property | Assessment | | |
| + | 27 | |---|---| | |
| + | 28 | | Correlation with clamp | Moderate at population level | | |
| + | 29 | | Individual classification | Poor; wide overlap between groups | | |
| + | 30 | | Tracking change within a person | Better, on a consistent assay | | |
| + | 31 | | Compartment | Reflects hepatic insulin resistance most directly | | |
| + | 32 | | Comparability between studies | Limited by assay and model version | | |
| + | 33 | ||
| + | 34 | The population-versus-individual distinction is the crux. A moderate population correlation is compatible with substantial misclassification of individuals, and an index that performs acceptably as a group descriptor may perform poorly as a personal one.{{r|wallace2004}} | |
| + | 35 | ||
| 25 | == References == | 36 | == References == |
| 26 | {{reflist}} | 37 | {{reflist}} |