Glucose-dependent insulinotropic polypeptide: difference between revisions
Diff·revision 49 → 50·08:22, 21 Aug 2025
Difference between revision 49 and revision 50 of Glucose-dependent insulinotropic polypeptide. 2 lines changed; the page grew by 427 bytes.
| Revision 49 — 20:31, 7 Aug 2025 NavboxNiko (talk) cite the trial publication rather than the press release 7,838 bytes ±0 | Revision 50 — 08:22, 21 Aug 2025 HyphenHarriet (talk) fix hyphenation per PP:MOS 8,265 bytes +427 | ||
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| 44 | GIP remained therapeutically unexploited for decades because insulinotropic beta-cell responses were thought to be lost in diabetes; the development of [[GLP-1 receptor agonist|GLP-1-directed monotherapy]] proceeded from that understanding. Dual GIP/GLP-1 receptor agonists ([[tirzepatide]], [[retatrutide]]) have demonstrated superior glycaemic control and weight loss compared to GLP-1 monotherapy in phase 3 trials, and are now approved or in development for both type 2 diabetes and obesity.{{r|frias2021,frias2022}} | 44 | GIP remained therapeutically unexploited for decades because insulinotropic beta-cell responses were thought to be lost in diabetes; the development of [[GLP-1 receptor agonist|GLP-1-directed monotherapy]] proceeded from that understanding. Dual GIP/GLP-1 receptor agonists ([[tirzepatide]], [[retatrutide]]) have demonstrated superior glycaemic control and weight loss compared to GLP-1 monotherapy in phase 3 trials, and are now approved or in development for both type 2 diabetes and obesity.{{r|frias2021,frias2022}} |
| 45 | 45 | ||
| + | 46 | The mechanisms underlying dual-agonist superiority are incompletely understood. Hypotheses include restoration of beta-cell GIP responsiveness through ambient GLP-1 signalling, adipose-tissue effects of dual agonism, and effects on the [[Arcuate nucleus|feeding centre]] in the hypothalamus. The GIP effect appears to be weight-loss dependent rather than independent, suggesting complementary rather than additive mechanisms. | |
| + | 47 | ||
| 46 | == References == | 48 | == References == |
| 47 | {{reflist}} | 49 | {{reflist}} |