Glucagon: difference between revisions
Diff·revision 16 → 17·11:44, 8 May 2025
Difference between revision 16 and revision 17 of Glucagon. 3 lines changed; the page grew by 288 bytes.
| Revision 16 — 20:23, 9 Apr 2025 BPC_Bramwell (talk) sentence case in headings per PP:MOS 5,754 bytes ±0 | Revision 17 — 11:44, 8 May 2025 FreightFenna (talk) reorder the analogues chronologically rather than alphabetically 6,042 bytes +288 | ||
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| 41 | The obstacle is that the same agonism raises blood glucose. The design solution is a fixed intramolecular ratio: [[Retatrutide|retatrutide]] engages GIP, GLP-1 and glucagon receptors; [[Survodutide|survodutide]] engages glucagon and GLP-1 receptors; efinopegdutide engages glucagon and GLP-1 receptors with a different balance and has been studied principally for hepatic fat. In each case the GLP-1 component is dosed sufficiently to dominate the net glycaemic effect. | 41 | The obstacle is that the same agonism raises blood glucose. The design solution is a fixed intramolecular ratio: [[Retatrutide|retatrutide]] engages GIP, GLP-1 and glucagon receptors; [[Survodutide|survodutide]] engages glucagon and GLP-1 receptors; efinopegdutide engages glucagon and GLP-1 receptors with a different balance and has been studied principally for hepatic fat. In each case the GLP-1 component is dosed sufficiently to dominate the net glycaemic effect. |
| 42 | 42 | ||
| + | 43 | Reported weight loss with the triple agonist at the highest doses studied exceeds that reported for GLP-1 monotherapy, though cross-trial comparison of this kind is unreliable and the programmes differ in population, duration and escalation schedule.{{r|coskun2022}} | |
| + | 44 | ||
| 43 | == References == | 45 | == References == |
| 44 | {{reflist}} | 46 | {{reflist}} |
| ⋮ | ⋮ | ||
| 53 | * [[Survodutide]] | 55 | * [[Survodutide]] |
| 54 | * [[Peptide aggregation]] | 56 | * [[Peptide aggregation]] |
| + | 57 | * [[Hypoglycaemia]] | |
| 55 | 58 | ||
| 56 | {{DEFAULTSORT:Glucagon}} | 59 | {{DEFAULTSORT:Glucagon}} |