Glucagon-like peptide-1: difference between revisions
Diff·revision 22 → 23·06:41, 26 Sep 2024
Difference between revision 22 and revision 23 of Glucagon-like peptide-1. 6 lines changed; the page grew by 985 bytes.
| Revision 22 — 23:56, 18 Sep 2024 MazdutideMads (talk) link to the policy rather than restating it 5,965 bytes ±0 | Revision 23 — 06:41, 26 Sep 2024 DrTitration (talk) add DOI 6,950 bytes +985 | ||
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| 41 | | Short-chain fatty acids | Products of colonic fermentation | Low to moderate | | 41 | | Short-chain fatty acids | Products of colonic fermentation | Low to moderate | |
| 42 | 42 | ||
| + | 43 | == Inactivation and clearance == | |
| + | 44 | {{figure|receptor|Ligand engagement of a class B G-protein-coupled receptor. GLP-1 binding stabilises an active conformation that couples to G<sub>s</sub> and raises intracellular cAMP.}} | |
| + | 45 | ||
| + | 46 | GLP-1 is cleaved between residues 8 and 9 by [[Dipeptidyl peptidase-4|dipeptidyl peptidase-4]], a widely expressed serine exopeptidase present both as a membrane protein on endothelium and as a soluble plasma form. The resulting GLP-1 (9–36) amide is at best weakly active at the [[GLP-1 receptor]] and has historically been regarded as an inactive metabolite, although a degree of independent cardiovascular activity has been proposed.{{r|deacon1995}} | |
| + | 47 | ||
| 43 | == References == | 48 | == References == |
| 44 | {{reflist}} | 49 | {{reflist}} |
| ⋮ | ⋮ | ||
| 50 | <ref name="holst1987">Holst JJ, Ørskov C, Nielsen OV, Schwartz TW. "Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut." ''FEBS Letters'' 211(2):169–174 (1987). PMID 3542566.</ref> | 55 | <ref name="holst1987">Holst JJ, Ørskov C, Nielsen OV, Schwartz TW. "Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut." ''FEBS Letters'' 211(2):169–174 (1987). PMID 3542566.</ref> |
| 51 | <ref name="kreymann1987">Kreymann B, Williams G, Ghatei MA, Bloom SR. "Glucagon-like peptide-1 7–36: a physiological incretin in man." ''The Lancet'' 2(8571):1300–1304 (1987). PMID 2890903.</ref> | 56 | <ref name="kreymann1987">Kreymann B, Williams G, Ghatei MA, Bloom SR. "Glucagon-like peptide-1 7–36: a physiological incretin in man." ''The Lancet'' 2(8571):1300–1304 (1987). PMID 2890903.</ref> |
| + | 57 | <ref name="deacon1995">Deacon CF, Johnsen AH, Holst JJ. "Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo." ''Journal of Clinical Endocrinology and Metabolism'' 80(3):952–957 (1995). PMID 7883856.</ref> | |
| 52 | 58 | ||
| 53 | {{DEFAULTSORT:Glucagon-like peptide-1}} | 59 | {{DEFAULTSORT:Glucagon-like peptide-1}} |