Glucagon-like peptide-1: difference between revisions
Diff·revision 11 → 12·05:45, 24 Jul 2024
Difference between revision 11 and revision 12 of Glucagon-like peptide-1. 5 lines changed; the page grew by 453 bytes.
| Revision 11 — 03:06, 17 Jul 2024 SatietySunniva (talk) de-orphan 3,005 bytes ±0 | Revision 12 — 05:45, 24 Jul 2024 ColdChainCleo (talk) correct molar mass 3,458 bytes +453 | ||
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| 15 | Cloning of the proglucagon gene in the early 1980s revealed two glucagon-like sequences downstream of glucagon itself, designated glucagon-like peptide-1 and glucagon-like peptide-2. The full-length GLP-1 (1–37) proved to be biologically inert; N-terminal truncation to GLP-1 (7–37) yielded a potent insulinotropic peptide.{{r|holst1987}} Physiological activity in humans was demonstrated shortly afterwards by infusion studies showing marked, glucose-dependent insulin release.{{r|kreymann1987}} | 15 | Cloning of the proglucagon gene in the early 1980s revealed two glucagon-like sequences downstream of glucagon itself, designated glucagon-like peptide-1 and glucagon-like peptide-2. The full-length GLP-1 (1–37) proved to be biologically inert; N-terminal truncation to GLP-1 (7–37) yielded a potent insulinotropic peptide.{{r|holst1987}} Physiological activity in humans was demonstrated shortly afterwards by infusion studies showing marked, glucose-dependent insulin release.{{r|kreymann1987}} |
| 16 | 16 | ||
| + | 17 | == Biosynthesis and secretion == | |
| + | 18 | {{main|Proglucagon}} | |
| + | 19 | ||
| + | 20 | Proglucagon is encoded by a single gene (''GCG'') and is processed differently in different tissues. In pancreatic alpha cells, prohormone convertase 2 predominates and glucagon is the principal product. In intestinal L cells and in some neurons of the caudal brainstem, prohormone convertase 1/3 predominates and the products are GLP-1, GLP-2 and the glicentin-related fragments.{{r|baggio2007}} | |
| + | 21 | ||
| 17 | == References == | 22 | == References == |
| 18 | {{reflist}} | 23 | {{reflist}} |